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Peptide Moisturiser

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DESCRIPTION

Peptide Moisturiser is packed with a mixture of serious skincare heavy lifters – four kinds of age-defying peptides and niacinamide. Nourish your skin and renew its glowing vibrance while keeping fine lines and wrinkles at bay. This formula takes advantage of new and exciting research into skin rejuvenation, which has found peptides to be a gentler alternative for anyone with skin too sensitive to tolerate Vitamin A or retinol products.

  • Contains four kinds of peptides – stimulates collagen/glycosaminoglycan production, reduces appearance of fine lines and wrinkles, improves skin firmness/elasticity
  • Contains niacinamide (vitamin B3) – antioxidant and anti-inflammatory, counteracts environmental damage, fights acne-causing bacteria, improves dull or uneven skin tone, prevents moisture loss, restores skin moisture barrier, reduces enlarged pores, stimulates collagen production, stimulates natural production of skin-strengthening ceramides, suppresses excess sebum
  • Skin types – all skin types
  • Skin concerns – dehydration, dullness, signs of ageing
CLINICAL INFORMATION

Topical Peptides for Skin

Peptides are short amino acid chains naturally responsible for a variety of functions in the body. As modern science has progressed, the functions of peptides have become better understood and new peptides have been synthesised for their beneficial, rejuvenating functions when applied to the skin.

Signal peptides (also known as matrikines or collagen stimulators) are often selected for use in topical skin care because they are able to stimulate or regenerate the natural production of skin matrix cells, which include collagen, elastin, proteoglycan, glycosaminoglycan and fibronectin. This has multiple skin benefits including improving unwanted effects of aging and photo-damage on the skin, increasing skin elasticity and smoothness, and reducing the appearance of fine lines and wrinkles.

Signal peptides are also known for wound healing, wrinkle smoothing, anti-oxidant, anti-microbial and brightening effects. Three peptides in this formula are signal peptides – acetyl tetrapeptide-5, biotinoyl tripeptide-1 and myristoyl tetrapeptide-12.

Cosmetics, May 2017, page 16

Journal of Cosmetic Dermatology, December 2019, pages 1693-1699

Cosmetics, March 2018, page 21

Acetyl Tetrapeptide-5

Acetyl tetrapeptide-5 is a signal peptide that is reported to improve the contour of the eye and reduce the appearance of eye puffiness, dark circles, and eyebags. Some small studies have shown it can help improve skin elasticity in the eye area, improve skin luminance and reduce darkness under the eyes, as well as reduce the volume of eyebags.

Indian Journal of Dermatology, Venereology and Leprology, January-February 2017, pages 9-18

Acetyl Hexapeptide-8

Acetyl hexapeptide-8 (also known as acetyl hexpeptide-3) is a synthetic peptide with hydrating and skin-restoring properties similar to other skin-nourishing peptides. It has the added, exciting property of a being neurotransmitter-inhibiting peptide, which means it may potentially reduce the appearance of lines and wrinkles caused by expressions (e.g. smile lines, crow’s feet). This potential has lead to acetyl hexapeptide-8 being known as “the botox of peptides”, but studies to confirm this effect are still ongoing.

Some studies of topical products containing acetyl hexapeptide-8 have found it improves skin structure, reduces the appearance of wrinkles, rejuvenates ageing skin, and improved skin value and self-image in patients with scars caused by cancer, hidradenitis and surgery.

Clinical Therapeutics, November 2020, pages e539-e548

Journal of Cosmetic and Laser Therapy, March 2013, pages 237-241

American Journal of Clinical Dermatology, April 2013, pages 147-153

Niacinamide

Niacinamide (also known as nicotinamide, or vitamin B3) has been found effective for a variety of skin appearance concerns including fine lines and wrinkles, acne, hyperpigmentation, red blotchiness, and sallow skin (yellowing). It also improves the overall structure, moisture and elasticity of skin, which helps maintain healthy and youthful-looking skin.

A double‐blinded, randomised controlled trial in 2005 of topical 5% niacinamide applied to the face for 12 weeks found significant improvements in skin appearance, including reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness and skin sallowness, as well as improved elasticity. Another double‐blinded, randomised controlled trial in 2008 of topical 4% niacinamide applied to the face for 8 weeks found significant improvements in wrinkle grades and skin roughness. These findings suggest that nicotinamide may be an effective agent for reducing signs of ageing.

Niacinamide increases the synthesis of collagen and other proteins important for the formation of keratin, filaggrin and involucrin (cells important to maintaining skin structure). It increases synthesis of ceramides, free fatty acids and cholesterol in the stratum corneum (outermost layer of the skin). A 2005 study found topical 2% niacinamide applied for 4 or 8 weeks significantly reduced water loss and increased hydration of the stratum corneum in patients with atopic dermatitis.

Topical niacinamide has been found useful for the treatment of acne and rosacea, due to its ability to suppress production of sebum, as well as anti-inflammatory, healing and skin barrier improving actions. A 2008 study found significant decrease in the number of pustules, comedomes, and papules with the application of 4% niacinamide topically for 8 weeks.

Niacinamide has been found to be effective at reducing excess pigmentation that can lead to uneven skin tone. It acts to suppress the action of melanosomes, which carry melanin (natural skin pigment) into keratinocytes (cells in the outermost layer of the skin). A 2010 double‐blinded, randomised controlled trial found that a topical formulation containing N‐acetyl glucosamine and 4% nicotinamide significantly reduced the detectable area of facial spots and the appearance of pigmentation.

Topically applied nicotinamide appears to reduce the immunosuppressive effects of UV radiation. It has also been found to help to protect the skin against oxidative stress. A number of studies have indicated that niacinamide is a potential agent for reducing actinic keratoses and preventing skin cancers, and this is still under ongoing investigation.

Side effects from topical application of nicotinamide are minor and rare, and may include mild burning, itching, and redness. These side effects improve with continued use.

Australasian Journal of Dermatology, August 2014, pages 169–175

Dermatologic Surgery, July 2005, pages 860-865

Journal of Dermatology, October 2008, pages 637-642

International Journal of Dermatology, March 2005, pages 197-202

Journal of the Turkish Academy of Dermatology, 2008

British Journal of Dermatology, January 2010, pages 435-441

Nutrition and Cancer, September 1997, pages 157-162

British Journal of Dermatology, December 2009, pages 1357-1364

British Journal of Dermatology, May 2010, pages 1138-1139

DIRECTIONS

Apply one to two pumps to the face and neck, once or twice a day. This moisturiser is designed to be applied after lighter products such as serums.

This product does not contain sunscreen. If applying during the day, use a broad-spectrum SPF 30+ sunscreen on treated areas for protection against sun damage.

INGREDIENTS

Aqua, Carthamus tinctorius oleosomes (Safflower), Niacinamide (Vitamin B3), Acetyl Tetrapeptide-5, Acetyl Hexapeptide-8, Biotinoyl Tripeptide-1, Myristoyl Tetrapeptide-12, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sodium carbomer, Tocopheryl acetate (Vitamin E), Benzoic acid, Sorbic acid

Storage

Store all medicines out of reach of children or pets.

Always check the expiry date on the label and do not use this product past the expiry date. Discard six months after opening.

Keep in a cool dry place where the temperature stays below 25°C. Avoid direct sunlight and heat.